From this point on, I will refer to only one of the above mentioned applications, because it is my preferred work environment. That is Microsoft Excel. I believe users of other spreadsheet applications will be able to adapt whatever I say from here for use in their own peculiar environments.
So, (when considering the automation I speak about) do not think about spreadsheet documents containing one or two click_able buttons that allow a user print a page or copy some cells from one sheet to another. Instead, I want you to picture an application(or Entreprise Information System) that customises the appearance of your spreadsheet workspace(to take advantage of maximum screen capital available on your PC), and offers you custom "floating" data entry forms.
At times, they would prefer to click a button that says "Print ABC", or "Print XYZ" report, instead of having to crawl all over the huge spreadsheet(and get "lost" every now and then), to highlight and print different report pages. Using a custom built data entry form to make data entries into 14 different cells in different parts of a table(at the same time/with one click) would, for them, be "heaven" compared to making the entries one at a time.
I believe using either of these two applications should not pose any problems for implementing your spreadsheet automation ideas. This is because both have always been "friendly", towards making it easy for users to get more functionality out of them by way of custom programming.
types of spreadsheet
examples of spreadsheet packages