I believe using either of these two applications should not pose any problems for implementing your spreadsheet automation ideas. This is because both have always been "friendly", towards making it easy for users to get more functionality out of them by way of custom programming.
A person with proven competence in this area CAN become "notorious" for developing spreadsheet applications, which eliminate drudgery from the process of using MS Excel to handle large amounts of data. Typically, work that takes hours or days will suddenly take minutes or seconds to finish.
So, (when considering the automation I speak about) do not think about spreadsheet documents containing one or two click_able buttons that allow a user print a page or copy some cells from one sheet to another. Instead, I want you to picture an application(or Entreprise Information System) that customises the appearance of your spreadsheet workspace(to take advantage of maximum screen capital available on your PC), and offers you custom "floating" data entry forms.
From this point on, I will refer to only one of the above mentioned applications, because it is my preferred work environment. That is Microsoft Excel. I believe users of other spreadsheet applications will be able to adapt whatever I say from here for use in their own peculiar environments.